Pancreozymin: This is a peptide compound of approximately thirty-three amino acids that is produced by the upper “intestinal mucosa” and also can be found in the “central nervous system”. It is also referred to as cholecystokinin or CCK. It triggers contractions in the gallbladder, discharge of pancreatic digestive or exocrine enzymes and also affects other functions of the gastrointestinal tract. It helps in stimulating the digestion of protein and fat.

Pancreozymin is synthesized by I-cells and is secreted in the duodenum, which is the first segment of the small intestine. It also can act as a hunger suppressant. Evidence from recent studies has submitted that it moreover shows a key role in prompting drug tolerance to opioids such as heroin and morphine and is partially associated in involvements of pain sensitivity during removal from opioids.

As a neuropeptide, CCK triggers satiety by acting on the CCK receptors that are widely disseminated thru out the CNS or central nervous system. In human beings, it has been submitted that CCK management creates nausea as well as anxiety and triggers a satiating effect. CCK-4 is used routinely for the stimulation of anxiety in humans and certain types of CCK have been shown to have variable effects. How the mechanism for hunger suppression works is believed to be a decrease in the rate of gastric emptying caused by CCK.